Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.50 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GPR3 | P46089 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.41 |
| ▸ | MELK | Q14680 | 1/20 | 0.41 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.41 |
| ▸ | TERT | O14746 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | TOP2A | P11388 | 2/20 | 0.39 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11898184 | 0.81 | JAK2 (0.50) | PARP1CHEK1JAK2RPS6KA3MELK | |
| SCHEMBL5313532 | 0.80 | PARP1 (0.50) | PARP1TNKS2PDPK1CA12ALOX15 | |
| SCHEMBL10525022 | 0.79 | PARP1 (0.44) | PARP1CHEK1JAK2RPS6KA3MELK | |
| SCHEMBL29421129 | 0.76 | PARP1 (0.55) | PARP1TNKS2PDPK1CA12ALOX15 | |
| SCHEMBL1665708 | 0.75 | KDM4E (0.46) | PARP1TNKS2PDPK1CA12ALOX15 | |
| SCHEMBL455351 | 0.75 | KDM4E (0.53) | PARP1TNKS2PDPK1CA12ALOX15 | |
| Iodide SCHEMBL4717590 | 0.74 | KDM4E (0.52) | PARP1TNKS2PDPK1CA12ALOX15 | |
| Hydrochloric Acid SCHEMBL3881151 | 0.74 | KDM4E (0.52) | PARP1TNKS2PDPK1CA12ALOX15 | |
| SCHEMBL27673186 | 0.74 | KDM4E (0.52) | PARP1TNKS2PDPK1CA12ALOX15 | |
| SCHEMBL669508 | 0.73 | PARP1 (0.70) | PARP1KDM4ECHEK1JAK2RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090258852-A1 | Inhibitors of Checkpoint Kinases | MERCK SHARP & DOHME CORP. | 2009-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258852-A1 | Inhibitors of Checkpoint Kinases | CHEK1, CHEK2, CDKN1A | PARP1 193/4885TNKS2 151/4885PDPK1 108/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.