Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 15/20 | 0.50 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | KDM4B | O94953 | 1/20 | 0.41 |
| ▸ | KDM5C | P41229 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.36 |
| ▸ | MELK | Q14680 | 1/20 | 0.36 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13659576 | 0.81 | PARP1 (0.50) | JAK2CHEK1PARP1RPS6KA3MELK | |
| SCHEMBL1159186 | 0.74 | PARP1 (0.53) | JAK2KDM4AKDM4BKDM5CKDM4C | |
| SCHEMBL10525022 | 0.73 | PARP1 (0.44) | JAK2CHEK1PARP1RPS6KA3MELK | |
| SCHEMBL30692017 | 0.71 | PARP1 (0.53) | JAK2KDM4AKDM4BKDM5CKDM4C | |
| SCHEMBL243725 | 0.71 | PARP1 (0.53) | JAK2KDM4AKDM4BKDM5CKDM4C | |
| SCHEMBL13659507 | 0.70 | JAK2 (0.43) | JAK2KCNH2CHEK1PARP1RPS6KA3 | |
| SCHEMBL2458264 | 0.70 | JAK2 (0.56) | JAK2KDM4AKDM4BKDM5CKDM4C | |
| SCHEMBL1178698 | 0.69 | KDM4A (0.73) | KDM4AKDM4BKDM5CKDM4CKDM5B | |
| Bromide SCHEMBL2246198 | 0.69 | PARP1 (0.52) | JAK2KDM4AKDM4BKDM5CKDM4C | |
| SCHEMBL20412216 | 0.69 | CLK1 (0.41) | KDM4AKDM4BKDM5CKDM4CKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200612-B1 | INHIBITORS OF JANUS KINASES | SCHERING CORP (US) | 2012-08-08 | — | — | EP | claimed |