Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 6/20 | 0.69 |
| ▸ | LMNA | P02545 | 5/20 | 0.69 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.69 |
| ▸ | PGR | P06401 | 4/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.69 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.69 |
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.66 |
| ▸ | CNR1 | P21554 | 1/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.66 |
| ▸ | USP2 | O75604 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | AR | P10275 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | TNF | P01375 | 2/20 | 0.57 |
| ▸ | IKBKB | O14920 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.56 |
| ▸ | PRKCA | P17252 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12087287 | 0.99 | HIF1A (0.70) | HIF1ALMNANR3C1PGRCYP3A4 | |
| SCHEMBL13659919 | 0.97 | HIF1A (0.70) | HIF1ALMNANR3C1PGRCYP3A4 | |
| SCHEMBL13659972 | 0.95 | HIF1A (0.72) | HIF1ALMNANR3C1PGRCYP3A4 | |
| SCHEMBL13407266 | 0.94 | HIF1A (0.62) | HIF1ALMNANR3C1PGRCYP3A4 | |
| SCHEMBL13407103 | 0.93 | HIF1A (0.63) | HIF1ALMNANR3C1PGRCYP3A4 | |
| SCHEMBL13659905 | 0.92 | HIF1A (0.70) | HIF1ALMNANR3C1PGRCYP3A4 | |
| SCHEMBL5147408 | 0.92 | HIF1A (0.72) | HIF1ALMNANR3C1PGRCYP3A4 | |
| SCHEMBL5148577 | 0.92 | HIF1A (0.72) | HIF1ALMNANR3C1PGRCYP3A4 | |
| SCHEMBL4956233 | 0.92 | HIF1A (0.72) | HIF1ALMNANR3C1PGRCYP3A4 | |
| SCHEMBL13659973 | 0.91 | HIF1A (0.75) | HIF1ALMNANR3C1PGRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090264393-A1 | NITROOXY DERIVATIVES OF GLUCOCORTICOIDS | NICOX S.A. (FR) | 2009-10-22 | — | — | US | disclosed |
| US-20090264394-A1 | NITROOXY DERIVATIVES OF GLUCOCORTICOIDS | NICOX S.A. (FR) | 2009-10-22 | — | — | US | disclosed |
| US-20090258849-A1 | NITROOXY DERIVATIVES OF GLUCOCORTICOIDS | NICOX S.A. | 2009-10-15 | — | — | US | disclosed |
| US-20080221073-A1 | Nitrooxy Derivatives of Glucocorticoids | NICOX S.A. (FR) | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221073-A1 | Nitrooxy Derivatives of Glucocorticoids | NR3C1, NR3C2, NR5A1 | HIF1A 3438/4885LMNA 4130/4885NR3C1 1/4885 |
| US-20090264393-A1 | NITROOXY DERIVATIVES OF GLUCOCORTICOIDS | NR3C1, NR3C2, NR5A1 | HIF1A 3438/4885LMNA 4130/4885NR3C1 1/4885 |
| US-20090264394-A1 | NITROOXY DERIVATIVES OF GLUCOCORTICOIDS | NR3C1, NR3C2, NR5A1 | HIF1A 3438/4885LMNA 4130/4885NR3C1 1/4885 |
| US-20090258849-A1 | NITROOXY DERIVATIVES OF GLUCOCORTICOIDS | NR3C1, NR3C2, NR5A1 | HIF1A 3438/4885LMNA 4130/4885NR3C1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.