Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7105672 | 1.00 | HRH3 (0.45) | HRH3BACE1KCNH2CHRNA7CYP3A4 | |
| SCHEMBL4304245 | 0.95 | HRH3 (0.44) | HRH3BACE1KCNH2CHRNA7CYP3A4 | |
| SCHEMBL7177824 | 0.84 | HRH3 (0.46) | HRH3CHRM1HTR2AMCHR1 | |
| SCHEMBL7177818 | 0.84 | HRH3 (0.46) | HRH3CHRM1HTR2AMCHR1 | |
| SCHEMBL13660620 | 0.81 | ALDH1A1 (0.48) | CHRNA7 | |
| SCHEMBL4438040 | 0.79 | HRH3 (0.66) | HRH3KCNH2CYP3A4CYP2C9 | |
| SCHEMBL4435944 | 0.79 | HRH3 (0.46) | HRH3BACE1 | |
| SCHEMBL4431777 | 0.79 | HRH3 (0.66) | HRH3KCNH2CYP3A4CYP2C9 | |
| SCHEMBL4294139 | 0.79 | HRH3 (0.66) | HRH3KCNH2CYP3A4CYP2C9 | |
| SCHEMBL6701198 | 0.79 | HRH3 (0.66) | HRH3KCNH2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090263322-A1 | OCTAHYDRO-INDOLIZINE AND QUINOLIZINE AND HEXAHYDRO-PYRROLIZINES | APODACA RICHARD | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090263322-A1 | OCTAHYDRO-INDOLIZINE AND QUINOLIZINE AND HEXAHYDRO-PYRROLIZINES | HRH4, HNMT, HRH1 | HRH3 7/4885BACE1 1680/4885KCNH2 470/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.