Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GBA1 | P04062 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | P2RY1 | P47900 | 6/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12872589 | 0.91 | NAMPT (0.42) | NAMPTKITKDRFLT3DGAT1 | |
| SCHEMBL12872730 | 0.90 | DGAT1 (0.44) | NAMPTKITKDRFLT3DGAT1 | |
| SCHEMBL12872577 | 0.87 | NAMPT (0.43) | NAMPTMEN1KMT2AKITKDR | |
| SCHEMBL1180414 | 0.86 | KDR (0.47) | NAMPTKITKDRFLT3DGAT1 | |
| SCHEMBL12872743 | 0.85 | FPR2 (0.49) | NAMPTKITKDRFLT3DGAT1 | |
| SCHEMBL12872582 | 0.84 | FPR2 (0.42) | NAMPTKITKDRFLT3DGAT1 | |
| SCHEMBL12872604 | 0.83 | DGAT1 (0.49) | NAMPTMEN1KMT2AKITKDR | |
| SCHEMBL12872751 | 0.83 | DGAT1 (0.50) | NAMPTMEN1KMT2AKITKDR | |
| SCHEMBL12872735 | 0.83 | DGAT1 (0.50) | NAMPTMEN1KMT2AKITKDR | |
| SCHEMBL12872736 | 0.83 | DGAT1 (0.46) | NAMPTKITKDRFLT3DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009126624-A1 | TRIAZOLO COMPOUNDS USEFUL AS DGAT1 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-10-15 | — | — | WO | disclosed |