Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 10/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.30 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.30 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13665452 | 0.91 | GCK (0.33) | GCK | |
| SCHEMBL13665435 | 0.88 | GCK (0.33) | GCK | |
| SCHEMBL13665416 | 0.85 | GCK (0.39) | GCKSMN1; SMN2 | |
| SCHEMBL13665448 | 0.83 | GCK (0.33) | GCK | |
| SCHEMBL13665684 | 0.82 | GCK (0.34) | GCKSMN1; SMN2 | |
| SCHEMBL1076711 | 0.80 | CHEK2 (0.36) | GCK | |
| SCHEMBL1075818 | 0.79 | GCK (0.33) | GCK | |
| SCHEMBL1075201 | 0.79 | KDM4E (0.44) | GCK | |
| SCHEMBL13665408 | 0.78 | GCK (0.33) | GCKNR3C1CYP3A4 | |
| SCHEMBL1677193 | 0.78 | XDH (0.44) | GCKSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009125873-A1 | FUSED RING COMPOUNDS AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-10-15 | — | — | WO | disclosed |