Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 3/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | TEK | Q02763 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12790198 | 0.91 | HTT (0.41) | METAP1HTTHSD17B10PDE4DMEN1 | |
| SCHEMBL12847501 | 0.86 | MAPT (0.39) | METAP1HTTHSD17B10MEN1KMT2A | |
| SCHEMBL13667088 | 0.84 | KDM4E (0.39) | METAP1HTTHSD17B10ALDH1A1HPGD | |
| SCHEMBL14723649 | 0.84 | SLC40A1 (0.45) | METAP1HTTHSD17B10MEN1KMT2A | |
| SCHEMBL12847422 | 0.83 | SRC (0.41) | METAP1PDE4DKDM4EBRAFTDP2 | |
| SCHEMBL2936138 | 0.79 | BRAF (0.43) | BRAFAAK1KDRAURKALCK | |
| SCHEMBL13667125 | 0.78 | SRC (0.39) | METAP1HTTHSD17B10ALDH1A1HPGD | |
| SCHEMBL12847306 | 0.78 | MAPT (0.43) | METAP1PDE4DMEN1KMT2AKDM4E | |
| SCHEMBL1133650 | 0.78 | KMT2A (0.48) | METAP1HTTHSD17B10PDE4DMEN1 | |
| SCHEMBL12847307 | 0.78 | BRAF (0.55) | HTTHSD17B10BRAFHCKSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009130487-A1 | ARYL-QUINOLYL COMPOUNDS AND THEIR USE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2009-10-29 | — | — | WO | disclosed |