Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 20/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10328516 | 0.88 | AXL (0.57) | AXLEGFRMETSRC | |
| SCHEMBL13667478 | 0.83 | AXL (0.57) | AXLEGFRMETSRC | |
| SCHEMBL10328526 | 0.79 | AXL (0.58) | AXLEGFRMETSRC | |
| SCHEMBL10328511 | 0.79 | AXL (0.49) | AXLEGFRMETSRC | |
| SCHEMBL10328530 | 0.76 | AXL (0.73) | AXLEGFRMETSRC | |
| SCHEMBL1592079 | 0.75 | AXL (0.67) | AXLEGFRMETSRC | |
| SCHEMBL10328505 | 0.74 | AXL (0.73) | AXLEGFRMETSRC | |
| SCHEMBL13667281 | 0.74 | LRRK2 (0.49) | AXLEGFRMET | |
| SCHEMBL1590945 | 0.73 | AXL (0.78) | AXLEGFRMETSRC | |
| SCHEMBL13667556 | 0.71 | AXL (0.70) | AXLEGFRMETSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009127417-A1 | QUINOLINE DERIVATIVES AS AXL KINASE INHIBITORS | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2009-10-22 | — | — | WO | disclosed |