Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 3/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 2/20 | 0.42 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1016143 | 0.87 | KMT2A (0.58) | KMT2AHSD17B10ALDH1A1CNR1CYP1A2 | |
| SCHEMBL1013115 | 0.83 | KMT2A (0.51) | KMT2AHSD17B10ALDH1A1CNR1EPAS1 | |
| SCHEMBL30263390 | 0.83 | SMN1; SMN2 (0.49) | KMT2AALDH1A1KDM4ECYP1A2MAPT | |
| SCHEMBL2733287 | 0.81 | ALDH1A1 (0.55) | KMT2AALDH1A1KDM4ECYP1A2MAPT | |
| SCHEMBL12575429 | 0.76 | NNMT (0.45) | PARP1ALDH1A1JAK2MAP4K4JAK1 | |
| SCHEMBL22584044 | 0.75 | NPSR1 (0.46) | KMT2APARP1ALDH1A1IKBKBKDM4E | |
| SCHEMBL28062810 | 0.73 | SMN1; SMN2 (0.55) | HSD17B10PARP1ALDH1A1JAK2IKBKB | |
| SCHEMBL27480494 | 0.72 | KMT2A (0.43) | KMT2AHSD17B10CNR1DPP4 | |
| SCHEMBL5189312 | 0.72 | CNR1 (0.48) | KMT2AALDH1A1CNR1EPAS1KDM4E | |
| SCHEMBL9589361 | 0.71 | KMT2A (0.53) | KMT2AHSD17B10PARP1ALDH1A1GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009130496-A1 | SUBSTITUTED PYRIMIDIN-5-CARBOXAMIDES 281 | ASTRAZENECA AB (SE) | 2009-10-29 | — | — | WO | disclosed |