Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 19/20 | 0.80 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1368205 | 0.95 | MCHR1 (0.80) | MCHR1 | |
| SCHEMBL1367999 | 0.88 | MCHR1 (0.66) | MCHR1 | |
| SCHEMBL4050394 | 0.88 | MCHR1 (0.72) | MCHR1NPC1 | |
| SCHEMBL15239106 | 0.84 | MCHR1 (1.00) | MCHR1 | |
| SCHEMBL15239108 | 0.84 | MCHR1 (1.00) | MCHR1 | |
| SCHEMBL1367239 | 0.83 | MCHR1 (0.79) | MCHR1NPC1RAB9A | |
| SCHEMBL1366902 | 0.82 | MCHR1 (0.82) | MCHR1 | |
| SCHEMBL1364654 | 0.82 | MCHR1 (0.77) | MCHR1 | |
| SCHEMBL15310571 | 0.82 | MCHR1 (0.77) | MCHR1 | |
| SCHEMBL15271947 | 0.81 | MCHR1 (0.84) | MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069327-B1 | NEW PYRIDONE DERIVATIVES WITH MCH ANTAGONISTIC ACTIVITY AND MEDICAMENTS COMPRISING THESE COMPOUNDS | BOEHRINGER INGELHEIM INT (DE) | 2013-10-16 | — | — | EP | claimed |
| US-8067590-B2 | Melanin-concentrating hormone (MCH) receptor antagonists; treating obesity, eating disorders, affective disorders, drug dependency; compounds are amino-functional pyridazin-3-one, 1H-pyridin-2-one or 3H-pyrimidin-4-one | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-11-29 | — | — | US | claimed |