Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 19/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1367999 | 0.89 | MCHR1 (0.66) | MCHR1 | |
| SCHEMBL1367069 | 0.88 | MCHR1 (0.80) | MCHR1NPC1 | |
| SCHEMBL1366902 | 0.85 | MCHR1 (0.82) | MCHR1 | |
| SCHEMBL1368205 | 0.85 | MCHR1 (0.80) | MCHR1 | |
| SCHEMBL15249805 | 0.84 | MCHR1 (1.00) | MCHR1 | |
| SCHEMBL15310571 | 0.83 | MCHR1 (0.77) | MCHR1SMN1; SMN2 | |
| SCHEMBL1364654 | 0.83 | MCHR1 (0.77) | MCHR1SMN1; SMN2 | |
| SCHEMBL1365170 | 0.82 | MCHR1 (0.76) | MCHR1 | |
| SCHEMBL13748605 | 0.82 | MCHR1 (0.76) | MCHR1 | |
| SCHEMBL4045403 | 0.80 | MCHR1 (0.67) | MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103478-A1 | PYRIDONE AND PYRIDAZINONE DERIVATIVES AS MCH ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-08-27 | — | — | WO | disclosed |