Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17B | O94768 | 1/20 | 0.45 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 6/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.40 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
| ▸ | CKS1B | P61024 | 1/20 | 0.39 |
| ▸ | SKP1 | P63208 | 1/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 3/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | ACACA | Q13085 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25691681 | 1.00 | STK17B (0.45) | STK17BSTK17ADRD2DRD3PBK | |
| SCHEMBL30125365 | 1.00 | STK17B (0.45) | STK17BSTK17ADRD2DRD3PBK | |
| SCHEMBL4475865 | 1.00 | STK17B (0.45) | STK17BSTK17ADRD2DRD3PBK | |
| SCHEMBL13671917 | 0.90 | STK17B (0.57) | STK17BSTK17ADRD2DRD3PBK | |
| SCHEMBL4480928 | 0.90 | STK17B (0.57) | STK17BSTK17ADRD2DRD3PBK | |
| SCHEMBL13671918 | 0.88 | STK17B (0.45) | STK17BSTK17ADRD2DRD3PBK | |
| SCHEMBL4477397 | 0.88 | STK17B (0.45) | STK17BSTK17ADRD2DRD3PBK | |
| SCHEMBL20674042 | 0.86 | BTK (0.47) | STK17BSTK17ADRD2MERTKCKS1B | |
| SCHEMBL29785350 | 0.86 | BTK (0.47) | STK17BSTK17ADRD2MERTKCKS1B | |
| SCHEMBL28385129 | 0.86 | BTK (0.47) | STK17BSTK17ADRD2MERTKCKS1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11672791-B2 | Tyrosine kinase inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2023-06-13 | — | — | US | disclosed |
| US-20230012676-A1 | TYROSINE KINASE INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2023-01-19 | — | — | US | disclosed |
| US-11110082-B2 | Tyrosine kinase inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2021-09-07 | — | — | US | disclosed |
| US-10434096-B2 | Tyrosine kinase inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2019-10-08 | — | — | US | disclosed |
| US-20190099411-A1 | TYROSINE KINASE INHIBITORS | MIDCAP FINANCIAL TRUST | 2019-04-04 | — | — | US | disclosed |
| US-20180008589-A1 | TYROSINE KINASE INHIBITORS | MIDCAP FINANCIAL TRUST | 2018-01-11 | — | — | US | disclosed |
| US-7601714-B2 | Pyrimidine derivatives useful as inhibitors of PKC-theta | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-10-13 | — | — | US | disclosed |
| US-7601714-B2 | Pyrimidine derivatives useful as inhibitors of PKC-theta | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-10-13 | — | — | US | disclosed |
| US-20080287410-A1 | PYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF PKC-THETA | BARBOSA ANTONIO J M | 2008-11-20 | — | — | US | disclosed |
| US-20080287410-A1 | PYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF PKC-THETA | BARBOSA ANTONIO J M | 2008-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287410-A1 | PYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF PKC-THETA | PRKCZ, PRKCQ, PRKCH | STK17B 591/4885STK17A 542/4885DRD2 2565/4885 |
| US-20190099411-A1 | TYROSINE KINASE INHIBITORS | TYRO3, AXL, RET | STK17B 1434/4885STK17A 908/4885DRD2 3996/4885 |
| US-11110082-B2 | Tyrosine kinase inhibitors | TYRO3, AXL, RET | STK17B 1434/4885STK17A 908/4885DRD2 3996/4885 |
| US-20230012676-A1 | TYROSINE KINASE INHIBITORS | TYRO3, AXL, RET | STK17B 1434/4885STK17A 908/4885DRD2 3996/4885 |
| US-10434096-B2 | Tyrosine kinase inhibitors | TYRO3, AXL, RET | STK17B 1434/4885STK17A 908/4885DRD2 3996/4885 |
| US-20180008589-A1 | TYROSINE KINASE INHIBITORS | TYRO3, AXL, RET | STK17B 1434/4885STK17A 908/4885DRD2 3996/4885 |
| US-11672791-B2 | Tyrosine kinase inhibitors | TYRO3, AXL, RET | STK17B 1434/4885STK17A 908/4885DRD2 3996/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.