Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY6 | Q15077 | 9/20 | 0.47 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.47 |
| ▸ | NT5E | P21589 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ST6GAL1 | P15907 | 1/20 | 0.34 |
| ▸ | P2RY2 | P41231 | 6/20 | 0.34 |
| ▸ | P2RY4 | P51582 | 6/20 | 0.34 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13151571 | 1.00 | P2RY6 (0.47) | P2RY6P2RY14NT5EABL1RIN1 | |
| SCHEMBL6365808 | 1.00 | P2RY6 (0.47) | P2RY6P2RY14NT5EABL1RIN1 | |
| SCHEMBL5531861 | 0.90 | P2RY6 (0.40) | P2RY6P2RY14NT5EABL1RIN1 | |
| SCHEMBL6932273 | 0.90 | POLB (0.44) | P2RY6P2RY14NT5EABL1RIN1 | |
| SCHEMBL12404747 | 0.90 | POLB (0.49) | P2RY6P2RY14NT5EABL1RIN1 | |
| SCHEMBL20215740 | 0.89 | P2RY6 (0.34) | P2RY6P2RY14NT5EABL1RIN1 | |
| SCHEMBL20459987 | 0.89 | P2RY6 (0.34) | P2RY6P2RY14NT5EABL1RIN1 | |
| SCHEMBL19981007 | 0.89 | P2RY6 (0.34) | P2RY6P2RY14NT5EABL1RIN1 | |
| SCHEMBL1937265 | 0.89 | P2RY6 (0.34) | P2RY6P2RY14NT5EABL1RIN1 | |
| SCHEMBL14946367 | 0.89 | P2RY6 (0.34) | P2RY6P2RY14NT5EABL1RIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160024061-A1 | PREPARATION OF 2'-FLUORO-2'-ALKYL-SUBSTITUTED OR OTHER OPTIONALLY SUBSTITUTED RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES | PHARMASSET, INC. | 2016-01-28 | — | — | US | disclosed |
| US-8492539-B2 | Preparation of 2′-fluoro-2′-alkyl-substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives | GILEAD PHARMASSET LLC (US) | 2013-07-23 | — | — | US | disclosed |
| US-8481713-B2 | Preparation of alkyl-substituted 2-deoxy-2-fluoro-D-ribofuranosyl pyrimidines and purines and their derivatives | GILEAD PHARMASSET LLC (US) | 2013-07-09 | — | — | US | disclosed |
| US-7601820-B2 | Preparation of alkyl-substituted 2-deoxy-2-fluoro-D-ribofuranosyl pyrimidines and purines and their derivatives | PHARMASSET, INC. (US) | 2009-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160024061-A1 | PREPARATION OF 2'-FLUORO-2'-ALKYL-SUBSTITUTED OR OTHER OPTIONALLY SUBSTITUTED RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES | NSUN2, FBL, RNGTT | P2RY6 543/4885P2RY14 696/4885NT5E 331/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.