Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL1B | P01584 | 4/20 | 0.52 |
| ▸ | BCHE | P06276 | 2/20 | 0.51 |
| ▸ | ACHE | P22303 | 2/20 | 0.51 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | LDLR | P01130 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13673110 | 1.00 | IL1B (0.52) | IL1BBCHEACHEP2RX7RAB9A | |
| SCHEMBL12955006 | 0.89 | P2RX7 (0.53) | IL1BP2RX7NPC1KMT2A | |
| SCHEMBL12955002 | 0.89 | P2RX7 (0.53) | IL1BP2RX7NPC1KMT2A | |
| SCHEMBL1021986 | 0.88 | IL1B (0.53) | IL1BBCHEACHEP2RX7RAB9A | |
| SCHEMBL1020350 | 0.88 | IL1B (0.53) | IL1BBCHEACHEP2RX7RAB9A | |
| SCHEMBL13672898 | 0.88 | P2RX7 (0.51) | IL1BP2RX7NPC1KMT2A | |
| SCHEMBL11955392 | 0.87 | IL1B (0.51) | IL1BBCHEACHEP2RX7RAB9A | |
| SCHEMBL13673108 | 0.87 | IL1B (0.51) | IL1BBCHEACHEP2RX7RAB9A | |
| SCHEMBL1018807 | 0.87 | IL1B (0.52) | IL1BBCHEACHEP2RX7RAB9A | |
| SCHEMBL1018860 | 0.87 | IL1B (0.52) | IL1BBCHEACHEP2RX7RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009118175-A1 | NOVEL P2X7R ANTAGONISTS AND THEIR USE | AFFECTIS PHARMACEUTICALS AG (DE) | 2009-10-01 | — | — | WO | disclosed |
| EP-2105164-A1 | Novel P2X7R antagonists and their use | Affectis Pharmaceuticals AG (DE) | 2009-09-30 | — | — | EP | disclosed |