Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.59 |
| ▸ | RAB9A | P51151 | 8/20 | 0.59 |
| ▸ | MAPT | P10636 | 6/20 | 0.59 |
| ▸ | MEN1 | O00255 | 5/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | HK1 | P19367 | 1/20 | 0.59 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.59 |
| ▸ | FBP1 | P09467 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 6/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.53 |
| ▸ | RELA | Q04206 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | AR | P10275 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4538229 | 0.83 | RECQL (0.60) | ALDH1A1RAB9AMAPTKDM4EHPGD | |
| SCHEMBL10657865 | 0.78 | KDM4E (0.55) | ALDH1A1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL4636395 | 0.78 | TSHR (0.72) | ALDH1A1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL1399840 | 0.76 | ALDH1A1 (0.76) | ALDH1A1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL12171395 | 0.76 | KDM4E (0.60) | ALDH1A1RAB9AKMT2AKDM4ENPC1 | |
| SCHEMBL3174985 | 0.75 | PARP1 (0.45) | ALDH1A1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL1804064 | 0.75 | MAPT (0.65) | ALDH1A1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL1091753 | 0.75 | ALDH1A1 (1.00) | ALDH1A1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL21586267 | 0.75 | HSD17B1 (0.70) | ALDH1A1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL12592119 | 0.75 | ALDH1A1 (0.65) | ALDH1A1RAB9AMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7605264-B2 | Heterocyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-10-20 | — | — | US | disclosed |
| US-7544808-B2 | Tricyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-06-09 | — | — | US | disclosed |