Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | HTR2B | P41595 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | CCR6 | P51684 | 1/20 | 0.32 |
| ▸ | CYP24A1 | Q07973 | 2/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.32 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.32 |
| ▸ | CYP27A1 | Q02318 | 1/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL474782 | 0.89 | HSD11B1 (0.39) | HSD11B1HTR2AHTR2CHTR2BKDM4E | |
| SCHEMBL208406 | 0.85 | HSD11B1 (0.51) | HSD11B1HTR2AHTR2CHTR2BKDM4E | |
| SCHEMBL474859 | 0.83 | HSD11B1 (0.38) | HSD11B1HTR2AHTR2CHTR2BKDM4E | |
| SCHEMBL474858 | 0.83 | HSD11B1 (0.38) | HSD11B1HTR2AHTR2CHTR2BKDM4E | |
| SCHEMBL2994422 | 0.83 | HSD11B1 (0.38) | HSD11B1HTR2AHTR2CHTR2BOPRM1 | |
| SCHEMBL2997454 | 0.83 | HSD11B1 (0.38) | HSD11B1HTR2AHTR2CHTR2BOPRM1 | |
| SCHEMBL10072278 | 0.82 | HTR2C (0.34) | HSD11B1HTR2AHTR2CHTR2BKDM4E | |
| SCHEMBL4515440 | 0.80 | FFAR4 (0.37) | HSD11B1HTR2AHTR2CHTR2BOPRM1 | |
| SCHEMBL2210049 | 0.79 | HSP90AA1 (0.32) | HSD11B1HTR2AHTR2CHTR2BKDM4E | |
| SCHEMBL2210048 | 0.79 | HSP90AA1 (0.32) | HSD11B1HTR2AHTR2CHTR2BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090264650-A1 | Prophylactic/Therapeutic Agent for Diabetes | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264650-A1 | Prophylactic/Therapeutic Agent for Diabetes | HSD11B1, HSD17B1, HSD11B2 | HSD11B1 1/4885HTR2A 4228/4885HTR2C 4208/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.