Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.64 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.55 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13675757 | 0.91 | TRPV1 (0.78) | TRPV1HDAC1SLC2A1MEN1ALDH1A1 | |
| SCHEMBL13675759 | 0.87 | HDAC1 (0.62) | TRPV1HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL7605964 | 0.82 | TRPV1 (0.58) | TRPV1MCHR1HDAC1HDAC3HDAC4 | |
| SCHEMBL7605961 | 0.82 | SLC2A1 (0.69) | TRPV1MCHR1HDAC1HDAC3HDAC4 | |
| SCHEMBL13675768 | 0.80 | TRPV1 (0.63) | TRPV1MCHR1MEN1HPGDKMT2A | |
| SCHEMBL13676135 | 0.79 | HDAC1 (0.54) | MCHR1HDAC1HDAC2MAPT | |
| SCHEMBL4001591 | 0.78 | TRPV1 (1.00) | TRPV1HDAC1MEN1ALDH1A1HPGD | |
| SCHEMBL4001584 | 0.78 | TRPV1 (1.00) | TRPV1HDAC1MEN1ALDH1A1HPGD | |
| SCHEMBL20538231 | 0.77 | HTT (0.69) | TRPV1MAOBMEN1ALDH1A1HPGD | |
| SCHEMBL13675665 | 0.76 | TRPV1 (0.80) | TRPV1HDAC1MEN1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090264424-A1 | VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS | AMGEN INC. | 2009-10-22 | — | — | US | disclosed |
| US-20090264424-A1 | VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS | AMGEN INC. | 2009-10-22 | — | — | US | disclosed |
| US-7582657-B2 | Treating inflammatory and neuropathic pain, headache, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, eye disorders, bladder disorders, psoriasis, skin disorders, asthma, herpes simplex | AMGEN INC. (US) | 2009-09-01 | — | — | US | disclosed |
| US-7582657-B2 | Treating inflammatory and neuropathic pain, headache, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, eye disorders, bladder disorders, psoriasis, skin disorders, asthma, herpes simplex | AMGEN INC. (US) | 2009-09-01 | — | — | US | disclosed |
| US-7579347-B2 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. (US) | 2009-08-25 | — | — | US | disclosed |
| US-7579347-B2 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. (US) | 2009-08-25 | — | — | US | disclosed |
| EP-1780196-A2 | Pyridine derivatives for use as vanilloid receptor ligands | Amgen, Inc (US) | 2007-05-02 | — | — | EP | disclosed |
| EP-1764358-A2 | Cyclic amides as vanilloid receptor ligands and their use in treatments of inflammatory and neuropathic pain | Amgen, Inc (US) | 2007-03-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264424-A1 | VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS | TRPV1, TRPV2, TRPV3 | TRPV1 1/4885MCHR1 421/4885HDAC1 1024/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.