Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 7/20 | 0.48 |
| ▸ | CTSV | O60911 | 4/20 | 0.48 |
| ▸ | CTSL | P07711 | 3/20 | 0.48 |
| ▸ | CTSK | P43235 | 7/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 3/20 | 0.38 |
| ▸ | HCK | P08631 | 1/20 | 0.37 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | ACE | P12821 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4449536 | 1.00 | CTSS (0.48) | CTSSCTSVCTSLCTSKCDK2 | |
| SCHEMBL4444574 | 1.00 | CTSS (0.48) | CTSSCTSVCTSLCTSKCDK2 | |
| SCHEMBL13677309 | 0.96 | CTSS (0.45) | CTSSCTSVCTSLCTSKCDK2 | |
| SCHEMBL7150612 | 0.96 | CTSS (0.45) | CTSSCTSVCTSLCTSKCDK2 | |
| SCHEMBL4452661 | 0.96 | CTSS (0.45) | CTSSCTSVCTSLCTSKCDK2 | |
| SCHEMBL4457925 | 0.96 | CTSS (0.45) | CTSSCTSVCTSLCTSKCDK2 | |
| SCHEMBL4449861 | 0.94 | CTSS (0.49) | CTSSCTSVCTSLCTSKHPGDS | |
| SCHEMBL4453053 | 0.94 | CTSS (0.53) | CTSSCTSVCTSLCTSKHPGDS | |
| SCHEMBL4459125 | 0.93 | CTSS (0.48) | CTSSCTSVCTSLCTSKHPGDS | |
| SCHEMBL4454201 | 0.93 | CTSS (0.48) | CTSSCTSVCTSLCTSKHPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090247471-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LTD. (GB) | 2009-10-01 | — | — | US | disclosed |
| US-20090247471-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LTD. (GB) | 2009-10-01 | — | — | US | disclosed |
| US-7425562-B2 | Inhibitors of cruzipain and other cysteine proteases | AMURA THERAPEUTICS LTD. (GB) | 2008-09-16 | — | — | US | disclosed |
| US-7425562-B2 | Inhibitors of cruzipain and other cysteine proteases | AMURA THERAPEUTICS LTD. (GB) | 2008-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247471-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | CPN1, CTRL, CPA1 | CTSS 21/4885CTSV 18/4885CTSL 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.