Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 7/20 | 0.45 |
| ▸ | CTSV | O60911 | 4/20 | 0.45 |
| ▸ | CTSL | P07711 | 3/20 | 0.45 |
| ▸ | CTSK | P43235 | 5/20 | 0.42 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.37 |
| ▸ | HCK | P08631 | 1/20 | 0.36 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4452661 | 1.00 | CTSS (0.45) | CTSSCTSVCTSLCTSKACE | |
| SCHEMBL4457925 | 1.00 | CTSS (0.45) | CTSSCTSVCTSLCTSKACE | |
| SCHEMBL13677309 | 1.00 | CTSS (0.45) | CTSSCTSVCTSLCTSKACE | |
| SCHEMBL4444574 | 0.96 | CTSS (0.48) | CTSSCTSVCTSLCTSKACE | |
| SCHEMBL13677166 | 0.96 | CTSS (0.48) | CTSSCTSVCTSLCTSKACE | |
| SCHEMBL4449536 | 0.96 | CTSS (0.48) | CTSSCTSVCTSLCTSKACE | |
| SCHEMBL4453053 | 0.90 | CTSS (0.53) | CTSSCTSVCTSLCTSKHPGDS | |
| SCHEMBL4449861 | 0.90 | CTSS (0.49) | CTSSCTSVCTSLCTSKHPGDS | |
| SCHEMBL4449598 | 0.90 | CTSS (0.51) | CTSSCTSVCTSLCTSKACE | |
| SCHEMBL13677290 | 0.90 | CTSS (0.51) | CTSSCTSVCTSLCTSKACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362052-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002057270-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |