Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 7/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1147962 | 0.77 | HSP90AA1 (0.40) | HSP90AA1HSP90AB1 | |
| SCHEMBL12553712 | 0.70 | HSP90AA1 (0.37) | HSP90AA1HSP90AB1 | |
| SCHEMBL1343116 | 0.69 | HSP90AA1 (0.38) | HSP90AA1HSP90AB1 | |
| SCHEMBL14286503 | 0.69 | HSP90AA1 (0.40) | HSP90AA1HSP90AB1 | |
| SCHEMBL1147799 | 0.69 | HSP90AA1 (0.36) | HSP90AA1HSP90AB1 | |
| SCHEMBL13677641 | 0.69 | HSP90AA1 (0.37) | HSP90AA1HSP90AB1 | |
| SCHEMBL14425291 | 0.69 | HSP90AA1 (0.37) | HSP90AA1HSP90AB1 | |
| SCHEMBL14425279 | 0.67 | HSP90AA1 (0.35) | HSP90AA1HSP90AB1 | |
| SCHEMBL1344466 | 0.66 | HSP90AA1 (0.54) | HSP90AA1HSP90AB1 | |
| SCHEMBL12713544 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7608635-B2 | heat shock protein 90 inhibitors; antiproliferative agents; angiogenesis inhibitors | SYNTA PHARMACEUTICALS CORP. (US) | 2009-10-27 | — | — | US | disclosed |
| US-7608635-B2 | heat shock protein 90 inhibitors; antiproliferative agents; angiogenesis inhibitors | SYNTA PHARMACEUTICALS CORP. (US) | 2009-10-27 | — | — | US | disclosed |