Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 15/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 10/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | DDO | Q99489 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.32 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1343116 | 0.84 | HSP90AA1 (0.38) | HSP90AA1HSP90AB1ALOX12ALOX15MEN1 | |
| SCHEMBL14286503 | 0.80 | HSP90AA1 (0.40) | HSP90AA1HSP90AB1ALOX12ALOX15MEN1 | |
| SCHEMBL1147962 | 0.79 | HSP90AA1 (0.40) | HSP90AA1HSP90AB1ALDH1A1MAPTHPGD | |
| SCHEMBL12553712 | 0.76 | HSP90AA1 (0.37) | HSP90AA1HSP90AB1ALOX15HSP90B1TRAP1 | |
| SCHEMBL1343626 | 0.76 | GAA (0.39) | HSP90AA1HSP90AB1ALOX12ALOX15MEN1 | |
| SCHEMBL1147799 | 0.75 | HSP90AA1 (0.36) | HSP90AA1HSP90AB1 | |
| SCHEMBL16588892 | 0.74 | GSK3B (0.34) | MEN1MAPTHPGDKMT2ADHFR | |
| SCHEMBL16541252 | 0.73 | HSP90AA1 (0.39) | HSP90AA1HSP90AB1ALOX12ALOX15MEN1 | |
| SCHEMBL1148781 | 0.72 | GAA (0.39) | HSP90AA1HSP90AB1ALOX12ALOX15MEN1 | |
| SCHEMBL1148628 | 0.71 | MEN1 (0.35) | ALOX12ALOX15MEN1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7608635-B2 | heat shock protein 90 inhibitors; antiproliferative agents; angiogenesis inhibitors | SYNTA PHARMACEUTICALS CORP. (US) | 2009-10-27 | — | — | US | disclosed |
| US-20070191445-A1 | heat shock protein 90 inhibitors; antiproliferative agents; angiogenesis inhibitors | LSI FINANCING LLC, AS ADMINISTRATIVE AGENT | 2007-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191445-A1 | heat shock protein 90 inhibitors; antiproliferative agents; angiogenesis inhibitors | HSP90AB1, HSP90AA1, HSP90AB2P | HSP90AA1 2/4885HSP90AB1 1/4885DAO 3616/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.