Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 8/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 8/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.34 |
| ▸ | MEN1 | O00255 | 6/20 | 0.34 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1343116 | 0.94 | HSP90AA1 (0.38) | HSP90AA1HSP90AB1KMT2AMEN1SIRT5 | |
| SCHEMBL1147962 | 0.84 | HSP90AA1 (0.40) | HSP90AA1HSP90AB1MAPK1ALDH1A1TP53 | |
| SCHEMBL1148628 | 0.83 | MEN1 (0.35) | KMT2AMEN1ALOX12ALOX15LMNA | |
| SCHEMBL16541252 | 0.82 | HSP90AA1 (0.39) | HSP90AA1HSP90AB1KMT2AMEN1SIRT5 | |
| SCHEMBL13677641 | 0.80 | HSP90AA1 (0.37) | HSP90AA1HSP90AB1KMT2AMEN1ALOX12 | |
| SCHEMBL1147883 | 0.76 | HSP90AA1 (0.37) | HSP90AA1HSP90AB1ALOX12LMNAMAPK1 | |
| SCHEMBL1343583 | 0.75 | ALDH1A1 (0.38) | HSP90AA1HSP90AB1KMT2AMEN1ALOX12 | |
| SCHEMBL1148531 | 0.75 | CHEK1 (0.34) | HSP90AA1HSP90AB1ALOX12LMNAMAPK1 | |
| SCHEMBL1148563 | 0.74 | HSP90AA1 (0.38) | HSP90AA1HSP90AB1KMT2AMEN1ALOX15 | |
| SCHEMBL1148623 | 0.74 | HSP90AA1 (0.35) | HSP90AA1HSP90AB1KMT2AMEN1ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080004266-A1 | Method for treating proliferative disorders associated with protooncogene products | LSI FINANCING LLC, AS ADMINISTRATIVE AGENT | 2008-01-03 | — | — | US | disclosed |
| US-20080004266-A1 | Method for treating proliferative disorders associated with protooncogene products | LSI FINANCING LLC, AS ADMINISTRATIVE AGENT | 2008-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004266-A1 | Method for treating proliferative disorders associated with protooncogene products | HSP90AB1, HSP90AB2P, HSP90AA1 | HSP90AA1 3/4885HSP90AB1 1/4885KMT2A 892/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.