Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 9/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 7/20 | 0.38 |
| ▸ | G6PD | P11413 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1343116 | 0.89 | HSP90AA1 (0.38) | HSP90AA1HSP90AB1G6PDMEN1KMT2A | |
| SCHEMBL1148563 | 0.82 | HSP90AA1 (0.38) | HSP90AA1HSP90AB1MEN1KMT2AALDH1A1 | |
| SCHEMBL14286503 | 0.82 | HSP90AA1 (0.40) | HSP90AA1HSP90AB1MEN1KMT2ASIRT5 | |
| SCHEMBL1343583 | 0.81 | ALDH1A1 (0.38) | HSP90AA1HSP90AB1MEN1KMT2AALDH1A1 | |
| SCHEMBL1148070 | 0.79 | HSP90AA1 (0.37) | HSP90AA1HSP90AB1MEN1KMT2AALDH1A1 | |
| SCHEMBL1147890 | 0.77 | THRA (0.38) | HSP90AA1HSP90AB1 | |
| SCHEMBL14425291 | 0.77 | HSP90AA1 (0.37) | HSP90AA1HSP90AB1CDK4CCND1ALDH1A1 | |
| SCHEMBL12060329 | 0.74 | HSP90AA1 (0.36) | HSP90AA1HSP90AB1 | |
| SCHEMBL12060326 | 0.73 | HSP90AA1 (0.36) | HSP90AA1HSP90AB1 | |
| SCHEMBL1148835 | 0.73 | HSP90AA1 (0.38) | HSP90AA1HSP90AB1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8969396-B2 | Method for treating a B-raf associated cancer with an Hsp90 inhibitor | SYNTA PHARMACEUTICALS CORP. (US) | 2015-03-03 | — | — | US | disclosed |
| US-8969396-B2 | Method for treating a B-raf associated cancer with an Hsp90 inhibitor | SYNTA PHARMACEUTICALS CORP. (US) | 2015-03-03 | — | — | US | disclosed |