Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.48 |
| ▸ | TEK | Q02763 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14642400 | 0.91 | TP53 (0.62) | TP53RXFP1MEN1KMT2AHTT | |
| SCHEMBL13679713 | 0.84 | TP53 (0.62) | TP53RXFP1MEN1KMT2AHTT | |
| SCHEMBL13679598 | 0.83 | TP53 (0.61) | TP53RXFP1MEN1KMT2AHTT | |
| SCHEMBL13679613 | 0.81 | TP53 (0.64) | TP53RXFP1MEN1KMT2AHTT | |
| SCHEMBL14642446 | 0.80 | TP53 (0.60) | TP53RXFP1MEN1KMT2AHTT | |
| SCHEMBL13679615 | 0.79 | MEN1 (0.70) | TP53RXFP1MEN1KMT2AHTT | |
| SCHEMBL14642401 | 0.79 | TP53 (0.58) | TP53RXFP1MEN1KMT2AHTT | |
| SCHEMBL14642437 | 0.77 | ALDH1A1 (0.66) | TP53RXFP1MEN1KMT2AHTT | |
| SCHEMBL13679712 | 0.77 | ALDH1A1 (0.75) | TP53RXFP1MEN1KMT2AHTT | |
| SCHEMBL14642405 | 0.77 | MAPT (0.73) | TP53RXFP1MEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1482928-B1 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS,COMPOSITIONS AND USES RELATED THERETO | CURIS INC (US) | 2009-09-23 | — | — | EP | disclosed |