Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 2/20 | 0.52 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13679541 | 0.87 | MAPT (0.59) | MAPTMEN1HTTKMT2AKDM4E | |
| SCHEMBL14615299 | 0.81 | MAPT (0.66) | MAPTMEN1HTTKMT2AKDM4E | |
| SCHEMBL15424127 | 0.81 | MAPT (0.68) | MAPTMEN1HTTKMT2AKDM4E | |
| SCHEMBL13679575 | 0.78 | MAPT (0.73) | MAPTMEN1HTTKMT2AKDM4E | |
| SCHEMBL13679552 | 0.77 | MAPT (0.69) | MAPTMEN1HTTKMT2AKDM4E | |
| SCHEMBL20145731 | 0.77 | MAPT (0.63) | MAPTMEN1HTTKMT2AKDM4E | |
| SCHEMBL12831265 | 0.77 | MAPT (0.73) | MAPTMEN1HTTKMT2AKDM4E | |
| SCHEMBL14615282 | 0.77 | MAPT (0.68) | MAPTMEN1HTTKMT2AKDM4E | |
| SCHEMBL13679601 | 0.76 | MAPT (0.82) | MAPTMEN1HTTKMT2AKDM4E | |
| SCHEMBL5822835 | 0.75 | MAPT (0.58) | MAPTMEN1HTTKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1482928-B1 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS,COMPOSITIONS AND USES RELATED THERETO | CURIS INC (US) | 2009-09-23 | — | — | EP | disclosed |