Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.64 |
| ▸ | HPSE | Q9Y251 | 5/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6263969 | 0.85 | MAPT (0.79) | MAPTFOXO1HPSETP53MEN1 | |
| SCHEMBL13679541 | 0.84 | MAPT (0.59) | MAPTFOXO1HPSEMEN1HTT | |
| SCHEMBL13679715 | 0.84 | MAPT (0.69) | MAPTTP53MEN1KMT2A | |
| SCHEMBL14615274 | 0.83 | MAPT (0.80) | MAPTFOXO1HPSETP53MEN1 | |
| SCHEMBL12831265 | 0.81 | MAPT (0.73) | MAPTTP53MEN1HTTKMT2A | |
| SCHEMBL13679601 | 0.81 | MAPT (0.82) | MAPTTP53MEN1HTTKMT2A | |
| SCHEMBL13679577 | 0.81 | MAPT (0.60) | MAPTFOXO1HPSETP53MEN1 | |
| SCHEMBL6243599 | 0.80 | SMN1; SMN2 (0.60) | MAPTFOXO1HPSETP53 | |
| SCHEMBL6246003 | 0.80 | HPSE (0.80) | MAPTHPSEMEN1KMT2AKDM4E | |
| SCHEMBL25425945 | 0.79 | FOXO1 (0.66) | MAPTFOXO1HPSETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8772275-B2 | Mediators of hedgehog signaling pathways, compositions and uses related thereto | CURIS, INC. (US) | 2014-07-08 | — | — | US | disclosed |
| US-8772275-B2 | Mediators of hedgehog signaling pathways, compositions and uses related thereto | CURIS, INC. (US) | 2014-07-08 | — | — | US | disclosed |
| US-8354397-B2 | Controlling cell differentiation, cell proliferation; anticancer agents | CURIS, INC. (US) | 2013-01-15 | — | — | US | disclosed |
| US-8354397-B2 | Controlling cell differentiation, cell proliferation; anticancer agents | CURIS, INC. (US) | 2013-01-15 | — | — | US | disclosed |