Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.61 |
| ▸ | NR2E3 | Q9Y5X4 | 2/20 | 0.60 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15557123 | 0.88 | TP53 (0.57) | TP53RXFP1NR2E3KMT2AKDM4E | |
| SCHEMBL13679597 | 0.86 | PDPK1 (0.65) | TP53RXFP1KMT2AKDM4EMAPT | |
| SCHEMBL13679710 | 0.84 | TP53 (0.67) | TP53RXFP1KMT2AKDM4EMAPT | |
| SCHEMBL13679549 | 0.82 | LDLR (0.78) | TP53RXFP1KMT2AKDM4EMAPT | |
| SCHEMBL27202465 | 0.81 | NPC1 (0.71) | TP53NR2E3FOXO1KMT2AKDM4E | |
| SCHEMBL13679581 | 0.81 | MEN1 (0.69) | TP53RXFP1KMT2AKDM4EMAPT | |
| SCHEMBL13679608 | 0.80 | TP53 (0.55) | TP53RXFP1KMT2AKDM4EMAPT | |
| SCHEMBL13679609 | 0.80 | TP53 (0.68) | TP53RXFP1KMT2AKDM4EMAPT | |
| SCHEMBL24049711 | 0.78 | KDM4E (0.79) | TP53NR2E3FOXO1KMT2AKDM4E | |
| SCHEMBL26552131 | 0.78 | KDM4E (0.79) | TP53NR2E3FOXO1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8772275-B2 | Mediators of hedgehog signaling pathways, compositions and uses related thereto | CURIS, INC. (US) | 2014-07-08 | — | — | US | disclosed |
| US-8354397-B2 | Controlling cell differentiation, cell proliferation; anticancer agents | CURIS, INC. (US) | 2013-01-15 | — | — | US | disclosed |
| EP-1482928-B1 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS,COMPOSITIONS AND USES RELATED THERETO | CURIS INC (US) | 2009-09-23 | — | — | EP | disclosed |