Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13679597 | 0.87 | PDPK1 (0.65) | TP53RXFP1MAPTMEN1HTT | |
| SCHEMBL13679713 | 0.84 | TP53 (0.62) | TP53RXFP1MAPTMEN1HTT | |
| SCHEMBL14642400 | 0.84 | TP53 (0.62) | TP53RXFP1MAPTMEN1HTT | |
| SCHEMBL13679613 | 0.83 | TP53 (0.64) | TP53RXFP1MAPTMEN1HTT | |
| SCHEMBL13679598 | 0.83 | TP53 (0.61) | TP53RXFP1MAPTMEN1HTT | |
| SCHEMBL13679582 | 0.80 | TP53 (0.61) | TP53RXFP1MAPTMEN1HTT | |
| SCHEMBL14642446 | 0.80 | TP53 (0.60) | TP53RXFP1MAPTMEN1HTT | |
| SCHEMBL13679712 | 0.79 | ALDH1A1 (0.75) | TP53RXFP1MAPTMEN1HTT | |
| SCHEMBL14642437 | 0.79 | ALDH1A1 (0.66) | TP53RXFP1MAPTMEN1HTT | |
| SCHEMBL13679710 | 0.79 | TP53 (0.67) | TP53RXFP1MAPTMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8772275-B2 | Mediators of hedgehog signaling pathways, compositions and uses related thereto | CURIS, INC. (US) | 2014-07-08 | — | — | US | disclosed |
| US-8354397-B2 | Controlling cell differentiation, cell proliferation; anticancer agents | CURIS, INC. (US) | 2013-01-15 | — | — | US | disclosed |
| EP-1482928-B1 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS,COMPOSITIONS AND USES RELATED THERETO | CURIS INC (US) | 2009-09-23 | — | — | EP | disclosed |