Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.67 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.67 |
| ▸ | LDLR | P01130 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 6/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13679549 | 0.90 | LDLR (0.78) | TP53RXFP1LDLRMAPTLMNA | |
| SCHEMBL13679582 | 0.84 | TP53 (0.61) | TP53RXFP1MAPTNPC1RAB9A | |
| SCHEMBL13679597 | 0.82 | PDPK1 (0.65) | TP53RXFP1MAPTNPC1RAB9A | |
| SCHEMBL14642393 | 0.81 | TP53 (0.72) | TP53RXFP1MAPTLMNAGAA | |
| SCHEMBL13679711 | 0.81 | TP53 (0.74) | TP53RXFP1MAPTLMNAGAA | |
| SCHEMBL13679567 | 0.81 | TP53 (1.00) | TP53RXFP1MAPTSMN1; SMN2LMNA | |
| SCHEMBL13679563 | 0.81 | TP53 (0.74) | TP53RXFP1MAPTLMNAGAA | |
| SCHEMBL13679608 | 0.79 | TP53 (0.55) | TP53RXFP1MAPTSMN1; SMN2LMNA | |
| SCHEMBL13679609 | 0.79 | TP53 (0.68) | TP53RXFP1MAPTLMNAMEN1 | |
| SCHEMBL24507633 | 0.78 | EPHX2 (0.55) | TP53LDLRMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1482928-B1 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS,COMPOSITIONS AND USES RELATED THERETO | CURIS INC (US) | 2009-09-23 | — | — | EP | disclosed |