Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.45 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.45 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.45 |
| ▸ | NR2E1 | Q9Y466 | 10/20 | 0.43 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.40 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.40 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.40 |
| ▸ | LDLR | P01130 | 1/20 | 0.40 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12975650 | 0.87 | NR2E1 (0.55) | MAPK14BRAFKDRTNNI3KMAP4K2 | |
| SCHEMBL2845565 | 0.80 | KDR (0.66) | MAPK14BRAFKDRTNNI3KMAP4K2 | |
| SCHEMBL2847430 | 0.79 | MAP4K2 (0.58) | MAPK14BRAFKDRTNNI3KMAP4K2 | |
| SCHEMBL12999017 | 0.76 | MET (0.47) | MAPK14BRAFKDRTNNI3KNR2E1 | |
| SCHEMBL2843359 | 0.75 | NR2E1 (0.55) | KDRNR2E1CSF1RKITPDGFRB | |
| SCHEMBL12999014 | 0.74 | KDR (0.53) | MAPK14BRAFKDRTNNI3KMAP4K2 | |
| SCHEMBL31718472 | 0.70 | NR2E1 (0.61) | NR2E1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3386993 | 0.69 | MAPK14 (0.53) | MAPK14BRAFMAP4K2MAP3K7NR2E1 | |
| SCHEMBL2840607 | 0.68 | KDR (0.56) | MAPK14BRAFKDRTNNI3KMAP4K2 | |
| SCHEMBL2847973 | 0.67 | KDR (0.74) | MAPK14BRAFKDRTNNI3KCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940844-B1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-09-30 | — | — | EP | disclosed |