Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR2E1 | Q9Y466 | 11/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.54 |
| ▸ | BRAF | P15056 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.54 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.53 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.53 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.53 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.53 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.53 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.53 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.49 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.49 |
| ▸ | CSF1R | P07333 | 2/20 | 0.49 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12999017 | 0.90 | MET (0.47) | NR2E1MAPK14BRAFKDRTNNI3K | |
| SCHEMBL2843359 | 0.88 | NR2E1 (0.55) | NR2E1KDRPSEN1PSEN2APH1B | |
| SCHEMBL2845565 | 0.88 | KDR (0.66) | NR2E1MAPK14BRAFKDRTNNI3K | |
| SCHEMBL2847430 | 0.87 | MAP4K2 (0.58) | NR2E1MAPK14BRAFKDRTNNI3K | |
| SCHEMBL13679856 | 0.87 | MAPK14 (0.45) | NR2E1MAPK14BRAFKDRTNNI3K | |
| SCHEMBL2847973 | 0.81 | KDR (0.74) | MAPK14BRAFKDRTNNI3KCSF1R | |
| SCHEMBL12999014 | 0.81 | KDR (0.53) | MAPK14BRAFKDRTNNI3KMAP3K7 | |
| SCHEMBL25403334 | 0.81 | KDR (0.65) | MAPK14BRAFKDRTNNI3KCSF1R | |
| SCHEMBL25404330 | 0.76 | CSF1R (0.60) | MAPK14BRAFKDRTNNI3KCSF1R | |
| SCHEMBL2840607 | 0.75 | KDR (0.56) | NR2E1MAPK14BRAFKDRTNNI3K |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100324062-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2010-12-23 | — | — | US | disclosed |
| WO-2007053343-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2007-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324062-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | SYK, SRC, FYN | NR2E1 1653/4885MAPK14 303/4885BRAF 78/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.