Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 19/20 | 0.56 |
| ▸ | RAF1 | P04049 | 13/20 | 0.56 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | LYN | P07948 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | BCR | P11274 | 1/20 | 0.47 |
| ▸ | FER | P16591 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1012649 | 0.89 | BRAF (0.70) | BRAFRAF1RIPK2JAK2ABL1 | |
| SCHEMBL18676482 | 0.83 | BRAF (0.64) | BRAFRAF1RIPK2JAK2ABL1 | |
| SCHEMBL18676593 | 0.83 | BRAF (0.65) | BRAFRAF1RIPK2JAK2ABL1 | |
| SCHEMBL13680216 | 0.81 | BRAF (0.82) | BRAFRAF1 | |
| SCHEMBL1012406 | 0.76 | BRAF (0.77) | BRAFRAF1RIPK2JAK2ABL1 | |
| SCHEMBL19916582 | 0.75 | RAB9A (0.54) | RAF1EGFRCSF1RFLT3MAPK11 | |
| SCHEMBL16692935 | 0.74 | BRAF (0.67) | BRAFRAF1RIPK2JAK2ABL1 | |
| SCHEMBL1012392 | 0.74 | BRAF (0.76) | BRAFRAF1RIPK2JAK2ABL1 | |
| SCHEMBL17278083 | 0.73 | BRAF (0.85) | BRAFRAF1 | |
| SCHEMBL18676405 | 0.73 | BRAF (0.59) | BRAFRAF1RIPK2JAK2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2947072-A1 | 1-(3-(6,7-DIMETHOXYQUINAZOLIN-4-YLOXY)PHENYL)-3-(5-(1,1,1-TRIFLUORO-2-METHYLPROPAN-2-YL)ISOXAZOL-3-YL)UREA AS RAF KINASE MODULATOR IN THE TREATMENT OF CANCER DISEASES | Ambit Biosciences Corporation (US) | 2015-11-25 | — | — | EP | disclosed |
| WO-2009117080-A1 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATON (US) | 2009-09-24 | — | — | WO | disclosed |