Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 3/20 | 0.60 |
| ▸ | EGFR | P00533 | 10/20 | 0.53 |
| ▸ | KDR | P35968 | 7/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.53 |
| ▸ | KIF5B | P33176 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | FLT4 | P35916 | 5/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.51 |
| ▸ | FLT1 | P17948 | 4/20 | 0.51 |
| ▸ | AXL | P30530 | 1/20 | 0.50 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.50 |
| ▸ | MERTK | Q12866 | 1/20 | 0.50 |
| ▸ | KIT | P10721 | 1/20 | 0.50 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2744934 | 0.85 | EGFR (0.57) | RAF1EGFRKDRFLT4FGFR1 | |
| SCHEMBL1012448 | 0.84 | KDR (0.73) | RAF1EGFRKDRRETKIF5B | |
| SCHEMBL5143476 | 0.84 | EGFR (0.56) | RAF1EGFRKDRRETKIF5B | |
| SCHEMBL5571167 | 0.82 | TRPA1 (0.57) | RAF1EGFRKDRFLT4FGFR1 | |
| SCHEMBL1011750 | 0.82 | KDR (0.64) | RAF1EGFRKDRRETKIF5B | |
| SCHEMBL1011699 | 0.82 | KDR (0.64) | RAF1EGFRKDRRETKIF5B | |
| SCHEMBL18676495 | 0.82 | RAF1 (0.60) | RAF1EGFRKDRRETKIF5B | |
| SCHEMBL24010114 | 0.81 | KDR (0.58) | RAF1EGFRKDRLCKFLT4 | |
| SCHEMBL666478 | 0.80 | RAF1 (0.52) | RAF1EGFRKDRRETKIF5B | |
| SCHEMBL665297 | 0.80 | RAF1 (0.52) | RAF1EGFRKDRRETLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117080-A1 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATON (US) | 2009-09-24 | — | — | WO | disclosed |