Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.56 |
| ▸ | KDR | P35968 | 9/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.56 |
| ▸ | FLT1 | P17948 | 7/20 | 0.56 |
| ▸ | FLT4 | P35916 | 7/20 | 0.56 |
| ▸ | RAF1 | P04049 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 3/20 | 0.49 |
| ▸ | AXL | P30530 | 2/20 | 0.47 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.47 |
| ▸ | MERTK | Q12866 | 2/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 2/20 | 0.43 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | CIT | O14578 | 1/20 | 0.43 |
| ▸ | GAK | O14976 | 1/20 | 0.43 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | STK10 | O94804 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5143475 | 0.88 | RAF1 (0.53) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL2744934 | 0.85 | EGFR (0.57) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL13680219 | 0.84 | RAF1 (0.60) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL20216698 | 0.83 | KDR (0.70) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL5571167 | 0.82 | TRPA1 (0.57) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL2744926 | 0.80 | KDR (0.53) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL24010114 | 0.79 | KDR (0.58) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL1401640 | 0.79 | KDR (0.65) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL1401709 | 0.78 | KDR (0.53) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL4576365 | 0.76 | RAF1 (0.49) | EGFRKDRFGFR1FLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9174947-B2 | c-Met modulators and methods of use | Exelixus, Inc. (US) | 2015-11-03 | — | — | US | disclosed |
| US-20070054928-A1 | c-Met modulators and methods of use | EXELIXIS, INC. (US) | 2007-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070054928-A1 | c-Met modulators and methods of use | FLT4, FLT1, MET | EGFR 124/4885KDR 4/4885FGFR1 270/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.