Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 18/20 | 0.62 |
| ▸ | RAF1 | P04049 | 6/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | FLT4 | P35916 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1012166 | 0.84 | BRAF (0.82) | BRAFRAF1KDRPDGFRB | |
| SCHEMBL19916632 | 0.77 | BRAF (0.73) | BRAFRAF1KDRPDGFRB | |
| SCHEMBL1012846 | 0.77 | BRAF (1.00) | BRAFRAF1KDRPDGFRB | |
| SCHEMBL18676593 | 0.77 | BRAF (0.65) | BRAFRAF1KDRPDGFRB | |
| SCHEMBL13680216 | 0.75 | BRAF (0.82) | BRAFRAF1 | |
| SCHEMBL19473583 | 0.73 | BRAF (0.80) | BRAFRAF1KDR | |
| SCHEMBL13680226 | 0.73 | BRAF (0.81) | BRAFRAF1KDR | |
| SCHEMBL16692935 | 0.72 | BRAF (0.67) | BRAFRAF1KDRPDGFRB | |
| SCHEMBL18676405 | 0.71 | BRAF (0.59) | BRAFRAF1KDRPDGFRB | |
| SCHEMBL1011946 | 0.71 | BRAF (1.00) | BRAFRAF1KDRPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117080-A1 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATON (US) | 2009-09-24 | — | — | WO | disclosed |