Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | CDC25B | P30305 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12898267 | 0.92 | SIRT6 (0.43) | HCAR3HTTSIRT6PDGFRBFGFR1 | |
| SCHEMBL26628821 | 0.90 | PDGFRB (0.49) | HCAR3HTTSIRT6PDGFRBFGFR1 | |
| SCHEMBL12190640 | 0.88 | PDGFRB (0.57) | HCAR3HTTPDGFRBFGFR1PDGFRA | |
| SCHEMBL15323319 | 0.87 | PDGFRB (0.49) | HCAR3HTTSIRT6PDGFRBFGFR1 | |
| SCHEMBL24500495 | 0.86 | HCAR3 (0.46) | HCAR3HTTSIRT6PDGFRBFGFR1 | |
| SCHEMBL12768213 | 0.86 | SIRT6 (0.43) | HCAR3HTTSIRT6PDGFRBFGFR1 | |
| SCHEMBL12190698 | 0.86 | CHEK1 (0.47) | HCAR3HTTPDGFRBFGFR1PDGFRA | |
| SCHEMBL29695047 | 0.86 | HCAR3 (0.46) | HCAR3HTTSIRT6PDGFRBFGFR1 | |
| SCHEMBL2696693 | 0.84 | PDGFRB (0.47) | HCAR3HTTSIRT6PDGFRBFGFR1 | |
| SCHEMBL29850630 | 0.84 | PDGFRB (0.60) | HCAR3HTTSIRT6PDGFRBFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582770-B2 | Viral polymerase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-09-01 | — | — | US | disclosed |