Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.55 |
| ▸ | RORB | Q92753 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16398901 | 0.88 | KDM4E (0.70) | KDM4EALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL923710 | 0.81 | KDM4E (0.67) | KDM4EALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL984311 | 0.79 | KDM4E (0.67) | KDM4EALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL13680417 | 0.78 | GAA (0.39) | KDM4EALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL496802 | 0.76 | ALDH1A1 (1.00) | KDM4EALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL6373670 | 0.74 | ALDH1A1 (0.56) | KDM4EALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL269275 | 0.74 | KDM4E (0.50) | KDM4EALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL18004116 | 0.74 | KDM4E (0.50) | KDM4EALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL496375 | 0.74 | KDM4E (0.75) | KDM4EALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL14172735 | 0.73 | KDM4E (0.45) | KDM4EALDH1A1SMN1; SMN2HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582664-B2 | Acylaminothiazole derivatives, preparation method thereof and use of same in therapeutics | SANOFI-AVENTIS (FR) | 2009-09-01 | — | — | US | disclosed |
| US-7582664-B2 | Acylaminothiazole derivatives, preparation method thereof and use of same in therapeutics | SANOFI-AVENTIS (FR) | 2009-09-01 | — | — | US | disclosed |