Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | XIAP | P98170 | 4/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8282843 | 0.82 | PSEN1 (0.53) | — | |
| SCHEMBL8283528 | 0.79 | SCN9A (0.38) | GAAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL13680416 | 0.78 | KDM4E (0.60) | GAARORCKDM4EDHODHALDH1A1 | |
| SCHEMBL8284039 | 0.76 | KMT2A (0.37) | GAAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3083725 | 0.70 | POLB (0.38) | RORCKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL14364277 | 0.67 | GAA (0.49) | GAAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL16398901 | 0.67 | KDM4E (0.70) | GAAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3094438 | 0.66 | POLB (0.58) | GAAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL6373670 | 0.65 | ALDH1A1 (0.56) | GAAKDM4EDHODHALDH1A1HPGD | |
| SCHEMBL269275 | 0.65 | KDM4E (0.50) | GAAKDM4EALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582664-B2 | Acylaminothiazole derivatives, preparation method thereof and use of same in therapeutics | SANOFI-AVENTIS (FR) | 2009-09-01 | — | — | US | disclosed |
| US-7582664-B2 | Acylaminothiazole derivatives, preparation method thereof and use of same in therapeutics | SANOFI-AVENTIS (FR) | 2009-09-01 | — | — | US | disclosed |