Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 2/20 | 0.53 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.53 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | HCK | P08631 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5252715 | 0.82 | KDR (0.50) | PIK3C3PIK3CDABL1EGFRHCK | |
| SCHEMBL13680666 | 0.81 | TGFBR1 (0.68) | TGFBR1TGFBR2PIK3CAFLT3HDAC6 | |
| SCHEMBL30186393 | 0.80 | HSD17B2 (0.47) | PIK3C3PIK3CACYP11B1CYP11B2 | |
| SCHEMBL14826051 | 0.80 | PIK3C3 (0.51) | TGFBR1TGFBR2PIK3C3PIK3CDABL1 | |
| SCHEMBL557143 | 0.80 | SMN1; SMN2 (0.44) | TGFBR1TGFBR2PIK3C3ALDH1A1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL6544504 | 0.78 | SMN1; SMN2 (0.43) | TGFBR1TGFBR2PIK3C3ALDH1A1L3MBTL1 | |
| SCHEMBL3185826 | 0.78 | PIK3C3 (0.45) | TGFBR1TGFBR2PIK3C3PIK3CDABL1 | |
| SCHEMBL729192 | 0.77 | KDR (0.52) | PIK3C3ALDH1A1KDRCYP11B1CYP11B2 | |
| SCHEMBL3196822 | 0.76 | TGFBR1 (0.54) | TGFBR1TGFBR2PIK3C3PIK3CDABL1 | |
| SCHEMBL3325842 | 0.76 | PIK3C3 (0.44) | TGFBR1TGFBR2PIK3C3ALDH1A1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |