Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 6/20 | 0.68 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.68 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.57 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 2/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | MERTK | Q12866 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15638648 | 0.85 | TGFBR1 (0.65) | TGFBR1TGFBR2DYRK1APDE4APDE3A | |
| SCHEMBL29676952 | 0.82 | TGFBR1 (1.00) | TGFBR1TGFBR2DYRK1A | |
| SCHEMBL18041609 | 0.82 | TGFBR1 (0.61) | TGFBR1TGFBR2DYRK1APDE4APDE3A | |
| SCHEMBL18041895 | 0.82 | TGFBR1 (1.00) | TGFBR1TGFBR2DYRK1A | |
| SCHEMBL30186375 | 0.81 | DYRK1A (0.57) | TGFBR1TGFBR2DYRK1AFAAHCYP3A4 | |
| SCHEMBL1832251 | 0.81 | DYRK1A (0.57) | TGFBR1TGFBR2DYRK1AFAAHRET | |
| SCHEMBL14320819 | 0.81 | DYRK1A (0.63) | TGFBR1TGFBR2DYRK1AFAAHCYP3A4 | |
| SCHEMBL30007309 | 0.81 | DYRK1A (0.63) | TGFBR1TGFBR2DYRK1AFAAHCYP3A4 | |
| SCHEMBL13680536 | 0.81 | TGFBR1 (0.53) | TGFBR1TGFBR2PIK3CAFLT3HDAC6 | |
| SCHEMBL13336394 | 0.81 | ALDH1A3 (0.53) | TGFBR1TGFBR2DYRK1AALDH1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |