Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.43 |
| ▸ | CCR8 | P51685 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 8/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | BRS3 | P32247 | 1/20 | 0.32 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680550 | 0.82 | CCR1 (0.46) | CCR1CCR8CYP2A6TGFBR1MAPK14 | |
| SCHEMBL2615817 | 0.76 | CCR1 (0.58) | CCR1CCR8CYP2A6TGFBR1MAPK14 | |
| SCHEMBL3422361 | 0.75 | CCR1 (0.75) | CCR1CCR8CYP2A6TGFBR1MAPK14 | |
| SCHEMBL13680517 | 0.73 | PGR (0.38) | RAB9ANPC1POLBMAPT | |
| SCHEMBL13680509 | 0.72 | CYP3A4 (0.40) | CYP2A6MEN1RAB9AKMT2ANPC1 | |
| SCHEMBL2614970 | 0.69 | CCR1 (0.65) | CCR1CCR8CYP2A6TGFBR1MAPK14 | |
| SCHEMBL2189142 | 0.68 | KMT2A (0.62) | CCR1CCR8CYP2A6TGFBR1METAP2 | |
| SCHEMBL647992 | 0.67 | MEN1 (0.68) | CCR1CCR8CYP2A6TGFBR1METAP2 | |
| SCHEMBL29963679 | 0.67 | MEN1 (0.68) | CCR1CCR8CYP2A6TGFBR1METAP2 | |
| SCHEMBL2614971 | 0.67 | MAPK14 (0.60) | CCR1CCR8CYP2A6TGFBR1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |