Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.51 |
| ▸ | CCR1 | P32246 | 1/20 | 0.48 |
| ▸ | CCR8 | P51685 | 1/20 | 0.48 |
| ▸ | ADK | P55263 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3421947 | 0.80 | CYP2A6 (0.65) | CYP2A6CCR1CCR8GRM5TGFBR1 | |
| SCHEMBL30146674 | 0.80 | CYP2A6 (0.65) | CYP2A6CCR1CCR8GRM5TGFBR1 | |
| SCHEMBL13680674 | 0.79 | CCR1 (0.52) | CYP2A6CCR1CCR8APPGRM5 | |
| SCHEMBL13680687 | 0.78 | CCR1 (0.55) | CYP2A6CCR1CCR8TGFBR1METAP2 | |
| SCHEMBL13051887 | 0.77 | CCR1 (0.59) | CYP2A6CCR1CCR8GRM5TGFBR1 | |
| SCHEMBL24673834 | 0.76 | CYP2A6 (0.54) | CYP2A6CCR1CCR8GRM5TGFBR1 | |
| SCHEMBL16835922 | 0.76 | CYP2A6 (0.54) | CYP2A6CCR1CCR8GRM5TGFBR1 | |
| SCHEMBL8134447 | 0.76 | CYP2A6 (0.50) | CYP2A6CCR1CCR8ADKAPP | |
| SCHEMBL1743453 | 0.76 | CYP2A6 (0.54) | CYP2A6CCR1CCR8GRM5TGFBR1 | |
| SCHEMBL29457509 | 0.76 | CYP2A6 (0.54) | CYP2A6CCR1CCR8GRM5TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |