Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 12/20 | 0.58 |
| ▸ | AXL | P30530 | 1/20 | 0.58 |
| ▸ | BTK | Q06187 | 4/20 | 0.56 |
| ▸ | ITK | Q08881 | 4/20 | 0.56 |
| ▸ | CDK7 | P50613 | 2/20 | 0.53 |
| ▸ | PLK4 | O00444 | 1/20 | 0.53 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | PAK4 | O96013 | 1/20 | 0.53 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.53 |
| ▸ | INSR | P06213 | 1/20 | 0.53 |
| ▸ | CDK1 | P06493 | 1/20 | 0.53 |
| ▸ | FES | P07332 | 1/20 | 0.53 |
| ▸ | ROS1 | P08922 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.53 |
| ▸ | FER | P16591 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16186619 | 0.82 | CDK8 (0.58) | CDK8AXLBTKITKCDK7 | |
| SCHEMBL4831566 | 0.78 | CDK8 (0.66) | CDK8AXLBTKITKCDK7 | |
| SCHEMBL4831501 | 0.78 | CDK8 (0.81) | CDK8AXLITKCDK7PLK4 | |
| SCHEMBL16135667 | 0.78 | PARP10 (0.54) | CDK8AXLBTKITKCDK7 | |
| SCHEMBL857038 | 0.77 | CDK8 (0.69) | CDK8AXLCDK7PLK4DCLK1 | |
| SCHEMBL13680569 | 0.76 | NPC1 (0.54) | BRD4 | |
| SCHEMBL31095069 | 0.76 | CDK8 (0.64) | CDK8AXLBTKITKCDK7 | |
| SCHEMBL29652435 | 0.75 | DYRK1A (0.48) | CDK8AXLBTKITKCDK7 | |
| SCHEMBL13854162 | 0.75 | CDK8 (0.56) | CDK8AXLCDK7PLK4DCLK1 | |
| SCHEMBL23912153 | 0.74 | BRD4 (0.57) | CDK1CDK5PIK3CGBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |