Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 3/20 | 0.53 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.48 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.47 |
| ▸ | AHR | P35869 | 3/20 | 0.45 |
| ▸ | CMA1 | P23946 | 2/20 | 0.45 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680572 | 0.89 | GRIA1 (0.62) | CRBNGRIA1CACNG8BRD4CREBBP | |
| SCHEMBL30648377 | 0.77 | EPHX2 (0.47) | NPC1MAPTRAB9APDE3BPDE3A | |
| SCHEMBL6744849 | 0.77 | KDM1A (0.55) | CRBNGRIA1CACNG8KDM1ABRD4 | |
| SCHEMBL29899623 | 0.77 | KDM1A (0.55) | CRBNGRIA1CACNG8KDM1ABRD4 | |
| SCHEMBL16321642 | 0.77 | ENPP3 (0.49) | CRBNGRIA1CACNG8KDM1ABRD4 | |
| SCHEMBL8265611 | 0.77 | CRBN (0.61) | CRBNGRIA1CACNG8BRD4CREBBP | |
| SCHEMBL16322861 | 0.76 | EIF2AK2 (0.49) | CRBNGRIA1CACNG8KDM1ABRD4 | |
| SCHEMBL13529011 | 0.76 | CRBN (0.61) | CRBNGRIA1CACNG8KDM1ABRD4 | |
| SCHEMBL13680628 | 0.75 | CRBN (0.48) | CRBNGRIA1CACNG8KDM1ABRD4 | |
| SCHEMBL23143561 | 0.74 | PDE3B (0.54) | CRBNKDM1ABRD4CREBBPAHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |