Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.56 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.56 |
| ▸ | NOS1 | P29475 | 5/20 | 0.51 |
| ▸ | NOS2 | P35228 | 4/20 | 0.51 |
| ▸ | NOS3 | P29474 | 3/20 | 0.51 |
| ▸ | PPM1D | O15297 | 1/20 | 0.50 |
| ▸ | CDC25A | P30304 | 1/20 | 0.45 |
| ▸ | CDC25B | P30305 | 1/20 | 0.45 |
| ▸ | CDC25C | P30307 | 1/20 | 0.45 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11256932 | 0.79 | PDE3B (0.63) | PDE3BPDE3ANOS1NOS2NOS3 | |
| SCHEMBL13680625 | 0.79 | CDC25A (0.56) | PDE3BPDE3ACDC25ACDC25BCDC25C | |
| SCHEMBL6197904 | 0.78 | PPM1D (0.55) | PDE3BPDE3APPM1DCDC25ACDC25B | |
| SCHEMBL13680991 | 0.77 | PDE3B (0.48) | PDE3BPDE3ANOS1NOS2NOS3 | |
| SCHEMBL11258651 | 0.76 | PDE3B (0.68) | PDE3BPDE3ANOS1NOS2NOS3 | |
| SCHEMBL13680565 | 0.74 | PDE3B (0.54) | PDE3BPDE3ANOS1NOS2NOS3 | |
| SCHEMBL13680627 | 0.72 | CA12 (0.51) | PDE3BPDE3ACDC25ACDC25BCDC25C | |
| SCHEMBL11260674 | 0.72 | PDE3B (1.00) | PDE3BPDE3ANOS1NOS2NOS3 | |
| SCHEMBL13680624 | 0.71 | NPC1 (0.51) | GLAKDM4ENPC1ALDH1A1MAPT | |
| SCHEMBL13680626 | 0.70 | QPCT (0.57) | KDM4ENPC1ALDH1A1HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |