Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.54 |
| ▸ | NOS1 | P29475 | 5/20 | 0.53 |
| ▸ | NOS2 | P35228 | 4/20 | 0.53 |
| ▸ | NOS3 | P29474 | 3/20 | 0.53 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
| ▸ | AKT2 | P31751 | 1/20 | 0.46 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | THPO | P40225 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | OGT | O15294 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
| ▸ | CDC25A | P30304 | 1/20 | 0.41 |
| ▸ | CDC25B | P30305 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11256932 | 0.80 | PDE3B (0.63) | PDE3BPDE3ANOS1NOS2NOS3 | |
| SCHEMBL13680558 | 0.78 | GRIA1 (0.59) | PDE3BPDE3ACDC25ACDC25BCDC25C | |
| SCHEMBL11251865 | 0.77 | PDE3B (0.60) | PDE3BPDE3ANOS1NOS2NOS3 | |
| SCHEMBL4256962 | 0.77 | NOS1 (0.68) | PDE3BPDE3ANOS1NOS2NOS3 | |
| SCHEMBL11258651 | 0.74 | PDE3B (0.68) | PDE3BPDE3ANOS1NOS2NOS3 | |
| SCHEMBL13680622 | 0.74 | PDE3B (0.56) | PDE3BPDE3ANOS1NOS2NOS3 | |
| SCHEMBL24348919 | 0.73 | BPGM (0.66) | PDE3BPDE3ANOS1NOS2NOS3 | |
| SCHEMBL17260645 | 0.72 | PDE3B (0.71) | PDE3BPDE3ANOS1NOS2NOS3 | |
| SCHEMBL13680450 | 0.71 | CA12 (0.53) | PDE3BPDE3ACYP2A6CCR1CCR8 | |
| SCHEMBL15592396 | 0.71 | PPM1D (0.66) | PDE3BPDE3ANOS1OGTSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |