Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 2/20 | 0.48 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.46 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.44 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.43 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.43 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.42 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22070487 | 0.82 | CYP4F2 (0.66) | KMOEGLN1CYP4F2CYP4A11GRIN2B | |
| SCHEMBL27163064 | 0.80 | SMN1; SMN2 (0.52) | CYP4F2CYP4A11MAP4K4CSNK1G2CLK4 | |
| SCHEMBL13680648 | 0.79 | HSD17B10 (0.51) | KMOEGLN1MAP4K4GRIN2BGRIN1 | |
| SCHEMBL13555905 | 0.79 | EGLN1 (0.46) | KMOEGLN1CYP4F2CYP4A11GRIN2B | |
| SCHEMBL15344198 | 0.78 | EGLN1 (0.47) | KMOEGLN1MAP4K4HSD17B1HSD17B2 | |
| SCHEMBL14831063 | 0.78 | ALDH1A1 (0.56) | KMOGRIN2BGRIN1ALDH1A1GAA | |
| SCHEMBL13680651 | 0.77 | IDO1 (0.47) | EGLN1MAP4K4HTTNPC1RAB9A | |
| SCHEMBL24405098 | 0.74 | KIT (0.48) | EGLN1GRIN2BGRIN1SYK | |
| SCHEMBL24405113 | 0.74 | EGLN1 (0.48) | KMOEGLN1MAP4K4CSNK1G2CLK4 | |
| SCHEMBL8264151 | 0.74 | DHODH (0.54) | MAP4K4CSNK1G2CLK4MKNK2MAP4K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |