Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | NEK2 | P51955 | 1/20 | 0.45 |
| ▸ | MAPK15 | Q8TD08 | 1/20 | 0.45 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | WNT3A | P56704 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | USP7 | Q93009 | 1/20 | 0.42 |
| ▸ | KMO | O15229 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680657 | 0.85 | FAAH (0.46) | EGLN1PIK3C3WNT3ACNR1MAP4K4 | |
| SCHEMBL25586500 | 0.81 | HSD17B10 (0.47) | HSD17B10EGLN1CHEK1FGFR1NEK2 | |
| SCHEMBL13680653 | 0.79 | KMO (0.48) | EGLN1MAP4K4KMOGRIN2BSYK | |
| SCHEMBL13680647 | 0.78 | MAP4K4 (0.67) | ADORA1EGLN1MAP4K4 | |
| SCHEMBL13680541 | 0.77 | HSD17B10 (0.79) | HSD17B10CNR1 | |
| SCHEMBL8265472 | 0.76 | HSD17B10 (0.66) | HSD17B10CNR1 | |
| SCHEMBL13304496 | 0.75 | ADORA3 (0.46) | HSD17B10ADORA3ADORA1PIK3C3 | |
| SCHEMBL22070487 | 0.75 | CYP4F2 (0.66) | HSD17B10EGLN1MAPK14WNT3AKMO | |
| SCHEMBL14988290 | 0.75 | HSD17B10 (0.55) | HSD17B10PIK3C3WNT3AADORA2AFYN | |
| SCHEMBL15344198 | 0.74 | EGLN1 (0.47) | ADORA1EGLN1MAP4K4KMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |