Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 11/20 | 0.54 |
| ▸ | CNR2 | P34972 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | STK4 | Q13043 | 1/20 | 0.51 |
| ▸ | STK3 | Q13188 | 1/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.51 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680656 | 0.86 | AOC3 (0.51) | AOC3GRIN2BKDM4ENPC1ALDH1A1 | |
| SCHEMBL13606215 | 0.85 | AOC3 (0.52) | AOC3CNR2MAPTTP53GRIN2B | |
| SCHEMBL4582036 | 0.82 | ADRB1 (0.54) | KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL30494244 | 0.82 | MAP4K4 (0.54) | AOC3CNR2PIK3CAMTOR | |
| SCHEMBL24721288 | 0.82 | PSEN1 (0.56) | AOC3CNR2PSEN1PSEN2APH1B | |
| SCHEMBL12611866 | 0.80 | MAPT (0.45) | AOC3CNR2MAPTTP53POLB | |
| SCHEMBL15344111 | 0.79 | PIK3CA (0.53) | AOC3CNR2MAPTPOLBLRRK2 | |
| SCHEMBL12525685 | 0.79 | AOC3 (0.65) | AOC3CNR2 | |
| SCHEMBL14992908 | 0.79 | AOC3 (0.62) | AOC3CNR2LRRK2PIK3CAMTOR | |
| SCHEMBL12525667 | 0.79 | AOC3 (0.59) | AOC3CNR2KCNH2MTORKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021130638-A1 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | CARNA BIOSCIENCES, INC. (JP) | 2021-07-01 | — | — | WO | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |