Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 10/20 | 0.43 |
| ▸ | CCR1 | P32246 | 1/20 | 0.43 |
| ▸ | CCR8 | P51685 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.38 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13681313 | 0.78 | CYP2A6 (0.45) | GRM5CYP2A6TGFBR1CCR1CCR8 | |
| SCHEMBL13680554 | 0.78 | GRM5 (0.53) | GRM5CYP2A6TGFBR1CCR1CCR8 | |
| SCHEMBL30146674 | 0.76 | CYP2A6 (0.65) | GRM5CYP2A6TGFBR1CCR1CCR8 | |
| SCHEMBL3421947 | 0.76 | CYP2A6 (0.65) | GRM5CYP2A6TGFBR1CCR1CCR8 | |
| SCHEMBL13051887 | 0.73 | CCR1 (0.59) | GRM5CYP2A6TGFBR1CCR1CCR8 | |
| SCHEMBL24673834 | 0.71 | CYP2A6 (0.54) | GRM5CYP2A6TGFBR1CCR1CCR8 | |
| SCHEMBL29457509 | 0.71 | CYP2A6 (0.54) | GRM5CYP2A6TGFBR1CCR1CCR8 | |
| SCHEMBL16835922 | 0.71 | CYP2A6 (0.54) | GRM5CYP2A6TGFBR1CCR1CCR8 | |
| SCHEMBL1743453 | 0.71 | CYP2A6 (0.54) | GRM5CYP2A6TGFBR1CCR1CCR8 | |
| SCHEMBL13680479 | 0.71 | CYP2A6 (0.54) | GRM5CYP2A6MAPTTGFBR1CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |